With great pleasure we present our Third International Workshop on The Local C- diac Renin-Angiotensin-Aldosterone System (RAAS), held at the Ochsner Clinic Foundation in November 2008. When this meeting was rst organized in 2002, we were pleased that all who were invited to participate in our rst workshop attended our program; and what is most satisfying, all of these participants returned for the second and this, the third workshop. In addition, we are delighted that a number of additional workers in this growing eld of investigation joined us for this third program. Over the years since our rst workshop, there is little doubt as to the existence of a local RAAS in the heart. Indeed, there is substantial evidence as to the existence of other local systems in brain, vessels, adrenal, and, as presented in the current workshop, the kidneys. What is even more stimulating intellectually, through dup- cation of local RAAS systems a remarkable yin-yang biological balance is provided by nature. Thus, in the current third workshop considerable evidence has accu- lated over the years for complicated local systems that serve to provide exquisite and unique local control of local organ functions.
The Local Cardiac Renin-Angiotensin Aldosterone System, Second Edition updates new findings on the local renin-angiotensin systems (RAS) with a focus on the local RAASs of the cardiovascular system and kidney.
Edward D. Frohlich, M.D., M.A.C.P, F.A.C.C., is the Alton Ochsner Distinguished Scientist at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Professor of Medicine and of Physiology at Louisiana State University School of Medicine, New Orleans, and Clinical Professor of Medicine and Adjunct Professor of Pharmacology at Tulane University School of Medicine, New Orleans. He is past Editor-in-Chief of the American Heart Association journal HYPERTENSION.
Richard N. Re, M.D., is the Section Head, Hypertension at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Ochsner's Scientific Director of Research.
From the reviews of the second edition:
"This book disseminates new findings about the local renin-angiotensin aldosterone system (RAAS) in the cardiovascular system and the kidneys ? . This is a great resource for anyone doing research into any cell or tissue that is regulated or potentially regulated by RAAS. ? Students beginning careers in research in this field will find this to be a great account of current research ? . As a gastrointestinal physiologist with a long-time interest in hormonal regulation of cell function, I found this book intriguing." (David L. Osborne, Doody's Review Service, June, 2010)
