The United Protectorate is under attack by the Brelac, a bloodthirsty reptilian alien race bent on destroying humanity. A dark alliance between the Brelac and the Vendetta, a separatist organization, looms over the Protectorate. The Brelac's onslaught brings forth the creation of the genetically engineered humanoid weapons called Reploids. Reploids are identical copies of real humans captured, killed, cloned, embedded with powerful psionic abilities, and programmed to serve the Brelac. The balance is upset when a weapon powerful enough to bring the Protectorate to its knees is about to be unleashed and the Protectorate's only hope of stopping it are Colin, Diane, and Kelly.