In Biggest Little Girl, unloved and abused 14-year-old Joey has run away from home in smalltown California in search of anything better. She's got a few dollars and a bus ticket north, but at a truck stop just 30 miles from home, she meets Jerry with his gold watch and wad of cash. Jerry buys Joey a hamburger and offers her a job in Reno?making deliveries?and desperate for someone to trust, she accepts. In Reno, the Biggest Little City in the World, shacked up in a motel, Jerry cuts off ??Joey's hair, gives her new clothes, and sends her out to run envelopes of product into casinos in exchange for money. Joey makes a new group of friends at the motel, all teenagers, and when Joey falls for the ringleader, Amber, they all start making big plans to scam Jerry and run to Portland like a makeshift family. It doesn't take long before everything starts to dissolve when the suppliers get shorted, Jerry gets desperate, and the future becomes a gamble with a deck that has already been stacked against her.

Joey is not the name she was born with, but it will be the name she dies with if she doesn't find a way out soon.