This book reports on cutting-edge research and best practices in the broad fiel of biomedical engineering. Based on the  XLVI Mexican Congress on Biomedical Engineering, CNIB 2023, held on November 2-4, 2023 in Villahermosa Tabasco, Mexico, this second volume of the proceedings covers research topics in biomechanics, materials and engineering design and manufacturing, with applications in prostheses design and development, tissue engineering, medical device assessment and healthcare management. All in all, this book provides a timely snapshot on state-of-the-art achievements in biomedical engineering and current challenges in the field. It addresses both researchers and professionals, and it is expect to foster future collaborations between the two groups, as well as international collaborations.