Full Description This groundbreaking work presents the Brain Metafunction Framework (BMF)-a comprehensive model that unifies neuroscience, cognition, identity, spirituality, and personhood. Rooted in three decades of research on coma, brain death, and disorders of consciousness, the BMF begins with a simple insight: all brain functions are deeply integrated, and this integration is essential to the unity of the human person. Rather than viewing the brain as a collection of isolated modules, the BMF describes it as a dynamically interconnected and hierarchically organized system that coordinates perception, memory, emotion, bodily regulation, symbolic thought, and volition. The book addresses fundamental questions: How does the brain create a coherent sense of self? How does it adapt, preserve identity, and bridge the physical and transphysical dimensions of human experience? Among the book's original contributions is the Metafunctional Theory of Perception, which reframes perception not as passive reception but as an active, generative process shaped by efferent projections. This "secret in plain sight" reveals how perception implicitly links the physical and transphysical, and offers new clinical tools for understanding conditions such as phantom limb syndrome, post-stroke deficits, trauma-related dissociation, hallucinations, and sensory loss. A detailed clinical table applies this theory across neurological and psychological disorders. The book also introduces Brain Metafunction Syndromes, a novel classification that explains how disruptions in integrative processes underlie coma, minimally conscious states, and other neurological conditions. Building upon this insight, A Refined Formulation of Human Death expands a model first proposed by the author in the 1990s, defining death as the irreversible loss of integrative brain function-a perspective with medical, ethical, and philosophical implications. Additional original concepts include Metafunctional Free Will, which explores how integration across conscious and unconscious systems supports autonomy and agency, and Brain Metafunction Ports, conceptualized as convergence zones where sensory, cognitive, emotional, and regulatory processes unify into coherent personal experience. The framework culminates in Brain Metafunction Transphysicalism, which proposes that the brain is not only the organ of consciousness but also a bridge to transphysical realities. This model invites engagement with theological questions about the soul, miracles, divine action, and the limits of materialist explanations. Throughout the book, discussions of perception, attention, memory, consciousness, and the unconscious are woven together with clinical case studies and reflections on neurological disorders. The BMF serves as a foundation for reinterpreting the brain's role in health and disease and offers a cohesive lens through which to understand identity, agency, and the unity of the self. Extending beyond neuroscience, the BMF informs bioethics and neuroethics, offering principled ways to assess disorders of consciousness, dementia, and end-of-life decisions. Philosophically, it challenges deterministic and reductionist models, presenting a richer view of human life that includes moral awareness and spiritual depth. Theologically, it aligns with Christian Theism, supporting a view of the human person as rooted in both the material and spiritual orders. The Brain Metafunction invites readers to reconsider what it means to be human-affirming the unity of body, mind, and soul, and revealing the profound mystery of a being capable of thought, love, agency, and transcendence.