This book presents an evidence-based framework that integrates the fundamental principles of Ayurveda with the precision of Green Nanotechnology, establishing the scientific foundation of Nano Ayurvedic Medicine (NAM). It explores the transformation of phytopharmaceuticals into nanoscale therapeutic systems through green synthesis and nano-engineering, enhancing bioavailability, pharmacokinetics, targeted delivery, and therapeutic efficacy while preserving the holistic principles of Ayurveda. The text comprehensively addresses nanoparticle design, physicochemical characterization, formulation strategies, ADME, pharmacodynamics, pharmacokinetics, cellular uptake, molecular mechanisms of action, biodistribution, nanotoxicology, quality assurance, standardization, translational research, and regulatory considerations essential for clinical development. Special emphasis is placed on the application of NAM in oncology, inflammatory, metabolic, infectious, neurodegenerative, and other complex disorders, supported by emerging preclinical evidence and clinical case studies that illustrate its translational potential while underscoring the need for rigorous scientific and clinical validation. Bridging nanomedicine, pharmaceutical sciences, systems biology, pharmacology, translational medicine, and Ayurveda, this book provides a comprehensive resource for researchers, clinicians, pharmaceutical scientists, regulatory professionals, academicians, and postgraduate students. It aims to advance scientifically validated integrative therapeutics and contribute to the evolution of precision, sustainable, and evidence-based healthcare.